Amoxicillin Sodium
Amoxicillin Sodium
CAS: 34642-77-8
Molecular Formula: C16H20N3NaO5S
Amoxicillin Sodium - Names and Identifiers
Amoxicillin Sodium - Physico-chemical Properties
| Molecular Formula | C16H20N3NaO5S |
| Molar Mass | 389.4 |
| Melting Point | 130℃ |
| Boling Point | 743℃ |
| Flash Point | >110°(230°F) |
| Water Solubility | Soluble in water. |
| Solubility | DMSO 78 mg/mL Water 78 mg/mL Ethanol <1 mg/mL |
| Appearance | Liquid |
| Storage Condition | under inert gas (nitrogen or Argon) at 2–8 °C |
| Sensitive | Easily absorbing moisture |
| Use | This product is for scientific research only and shall not be used for other purposes. |
Amoxicillin Sodium - Risk and Safety
| RTECS | XH8300000 |
Amoxicillin Sodium - Upstream Downstream Industry
| Raw Materials | Amoxicillin |
Amoxicillin Sodium - Standard
Authoritative Data Verified Data
(2S,5R,6R)-3, 3-dimethyl-6-[(R)-( -)-2-amino -2-(4-hydroxyphenyl) acetamido]-7-oxo-4-thia-1-azabicyclo [3.2.0] Sodium heptane-2-carboxylate. Calculated as anhydrous, containing amoxicillin (according to C16H19N305S) shall not be less than 80.0%.
Last Update：2024-01-02 23:10:35
Amoxicillin Sodium - Trait
Authoritative Data Verified Data
- This product is white or off-white powder or crystal; Odorless or slightly odorous; With hygroscopicity.
- This product is soluble in water, slightly soluble in ethanol, insoluble in ether.
specific rotation
take this product, precision weighing, adding water to dissolve and quantitative dilution to make a solution containing about 2.5mg per lml, according to the law (General rule 0621), the specific rotation is 240 ° to 290 °.
Last Update：2022-01-01 13:31:42
Amoxicillin Sodium - Introduction
Sodium Amoxicillin is a β-lactam antibiotic, lytic bacteria, and has a moderate antibacterial spectrum.
Last Update：2022-10-16 17:24:46
Amoxicillin Sodium - Differential diagnosis
Authoritative Data Verified Data
- take an appropriate amount of this product, according to amoxicillin identification item (1) test, showed the same results.
- in the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution.
- The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 1152).
- This product shows the reaction of sodium salt identification (1) (General rule 0301).
- two items (1) and (2) above can be selected as one item.
Last Update：2022-01-01 13:31:42
Amoxicillin Sodium - Exam
Authoritative Data Verified Data
alkalinity
take an appropriate amount of this product, add water to dissolve and make a solution containing 0.lg per lml, and determine it according to law (General 0631). The pH value should be 8.0~10.0.
clarity and color of solution
take 5 parts of this product, each 0.6g, respectively, after adding water 5ml to dissolve, the solution should be clear and colorless; If it is turbid, compare with No. 1 turbidity standard solution (General rule 0902 first method), shall not be more concentrated; If the color is developed, it shall not be deeper in comparison with the yellow or yellow-green standard colorimetric solution No. 5 (general principles 0901 first method). When the solution is first dissolved, it can show a short pink color.
Related substances
take an appropriate amount of this product, precision weighing, add mobile phase A to dissolve and quantitatively dilute before use. 0 mg of the solution was used as A test solution; 1ml was accurately weighed, placed in A 100ml measuring flask, diluted to the scale with mobile phase A, and shaken to obtain A control solution. Amoxicillin dimer (relative retention time is about 4.1) if there are impurity peaks in the chromatogram of the test solution. The peak area shall not be more than 3 times (3.0%) of the main peak area of the control solution; The peak area of other individual impurities shall not be more than 2 times (2.0%) of the main peak area of the control solution; the sum of each impurity peak area shall not be greater than 9 times (9.0%) of the main peak area of the control solution.
residual solvent
precision weigh 0.25g of this product, place it in the top empty bottle, add 5ml of water to dissolve, seal, and use it as a test solution. Precision weigh the appropriate amount of ethanol and methyl acetate, A solution containing about 0.3mg of ethanol and 0.2mg of methyl acetate per 1 ml was prepared by quantitative dilution with water, and 5ml was accurately weighed, placed in a headspace bottle, sealed, and used as a reference solution. Determined according to the residual solvent assay (General 0861 second method). Capillary column with 6% cyanopropylphenyl-94% dimethylpolysiloxane (or similar polar) as stationary liquid; Initial temperature is 33 ° C. For 6 minutes, the temperature was increased to 200°C at a rate of 30°C per minute for 6 minutes; The inlet temperature was 250°C. The detector temperature was 250°C; The equilibrium temperature of the headspace bottle was 80°C, the equilibration time was 30 minutes; The control solution was injected in Headspace, and the chromatogram was recorded. The resolution between peaks shall meet the requirements. The test solution and the reference solution were injected by Headspace, and the chromatograms were recorded. According to the external standard method to calculate the peak area, the residual amount of ethanol and methyl acetate should be in accordance with the provisions.
2-ethylhexanoic acid
take this product, determination according to law (General Principles 0873), not over 1.0%.
moisture
take this product, according to the moisture determination method (General 0832 first method 1), the water content shall not exceed 3.0%.
visible foreign body
take 5 parts of this product, each 2g, plus particle inspection water dissolution, inspection according to law (General 0904), should comply with the provisions. (For aseptic dispensing)
insoluble particles
Take 3 parts of this product, and make a solution containing 50mg per 1 ml with water for particle inspection, and check it according to law (General rule 0903), no more than 6000 particles with lOum or more and no more than 600 particles with 25um and 25um in each lg sample. (For aseptic dispensing)
bacterial endotoxin
take this product, check according to law (General rule 1143), each 1 mg of amoxicillin (according to C16H19N3O5S) in the amount of endotoxin should be less than 0.15EU. (For injection)
sterile
take this product, dissolve and dilute with appropriate solvent, after membrane filtration treatment, inspection according to law (General rule 1101), should comply with the provisions. (For aseptic dispensing)
Last Update：2022-01-01 13:31:43
Amoxicillin Sodium - Content determination
Authoritative Data Verified Data
take the appropriate amount of this product, precision weighing, and mobile phase dissolution and quantitative dilution to make a solution containing about 0.5mg per lml, as a test solution, according to the method under amoxicillin, that's right.
Last Update：2022-01-01 13:31:44
Amoxicillin Sodium - Category
Authoritative Data Verified Data
B-lactam antibiotics, penicillins.
Last Update：2022-01-01 13:31:44
Amoxicillin Sodium - Storage
Authoritative Data Verified Data
sealed and stored in a dry place.
Last Update：2022-01-01 13:31:44
Amoxicillin Sodium - Amoxicillin Sodium for injection
Authoritative Data Verified Data
This product is a sterile powder of amoxicillin sodium. Calculated as anhydrous, containing amoxicillin (according to C16H19N305S) shall not be less than 80.0%; Calculated as the average amount of juice, containing amoxicillin (according to C16H19N305S) shall be 90.0% ~ 110.0% of the label amount.
trait
This product is white or off-white powder or crystal.
identification
take this product, according to Amoxicillin Sodium under the identification test, showed the same results.
examination
- the clarity and color of the solution take 5 bottles of this product, and add water according to the labeled amount to make about 0 per 1 ml. lg solution, the solution should be clear and colorless; If it is turbid, it should not be more concentrated than the 1# turbidity standard solution (General 0902 first method); If it is colored, no deeper color shall be compared with the yellow or yellow-green standard colorimetric solution No. 6 (General rule 0901, Method 1). When the solution is first dissolved, it can be a short-lived pink.
- the moisture content of this product shall not exceed 0832 as determined by the method for determination of moisture (General rule 3.5%, first method 1).
- insoluble particles this product is taken, and the labeled amount is added to the particle inspection water to make a solution containing 50mg per 1 ml, which is inspected according to law (General rule 0903), and the labeled amount is 1. The conversion below Og is per l. No more than 6000 particles with lOum and more than 10um and no more than 600 particles with 25um and more than 25um in the Og sample; The labeled amount is l.Og or more (including l.Og) no more than 6000 particles of 10um and lOum in each sample container, and no more than 600 particles of 25um and 25um.
- alkalinity, related substances, bacterial endotoxin and sterility shall be checked according to the method under Amoxicillin Sodium, and shall be in accordance with the regulations.
- others should comply with the relevant provisions under injection (General 0102).
Content determination
The contents under the item of loading amount difference were obtained by measuring according to the method under the item of Amoxicillin Sodium.
category
with Amoxicillin Sodium.
specification
Based on C16H19N305S (l )0.5g (2) 1.0g(3)2.0g
storage
light shielding, sealed storage.
Last Update：2022-01-01 13:31:45
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Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
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Product Name: Na-6-[D-a-Amino-p-hydroxyphenylacetamido]penicillanicacid Request for quotationCAS: 34642-77-8
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Product Name: Amoxicillin sodium Visit Supplier Webpage Request for quotationCAS: 34642-77-8
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Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
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Product Name: Amoxycillin sodium Visit Supplier Webpage Request for quotationCAS: 34642-77-8
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Mobile: 609-228-6898
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View History
Amoxicillin Sodium
basfursol3ga
FEMA 2651
Sulphur Blue 3R.
Lithium perchlorate trihydrate
硼化铬
RITODRINE
S1RA
C.I. 59040
ACETYLSUCCINIC ACID DIMETHYL ESTER
basfursol3ga
FEMA 2651
Sulphur Blue 3R.
Lithium perchlorate trihydrate
硼化铬
RITODRINE
S1RA
C.I. 59040
ACETYLSUCCINIC ACID DIMETHYL ESTER
Raw Materials for Amoxicillin Sodium